Misfolding & Disease

Protein misfolding occurs when a polypeptide chain fails to adopt its functional native 3D conformation. Misfolded prote...

The kinetics of aggregation typically follow a sigmoidal curve characterized by a rate-limiting lag phase (primary nucle...

Amyloid fibril formation follows nucleation-dependent polymerization kinetics characterized by a sigmoidal time course. ...

Amyloidogenesis is the process by which proteins assemble into ordered, insoluble fibrils with a cross-β structure. Prio...

Modern therapeutic approaches to protein aggregation diseases exploit mechanistic insights from aggregation kinetics to ...

Pin1 is a unique peptidyl-prolyl isomerase that regulates protein conformation by catalyzing cis-trans isomerization of ...

Ribosomopathies are diseases caused by defects in ribosome biogenesis or function, manifesting with tissue-specific phen...

Prion diseases are fatal neurodegenerative disorders caused by the self-propagating misfolding of the prion protein (PrP...