Advanced Topics

IDPs challenge the traditional structure-function paradigm by existing as dynamic conformational ensembles. Their disord...

SLiMs are compact, degenerate amino acid sequences (3-10 residues) that mediate transient protein-protein interactions. ...

Inteins are autocatalytic protein domains that excise themselves from precursor polypeptides while ligating the flanking...

Liquid-liquid phase separation (LLPS) is the process by which proteins and nucleic acids demix from the cytoplasm to for...

Quaternary structure describes the assembly of multiple polypeptide subunits into functional protein complexes. Alloster...