Triptorelin GnRH for sale is available in lyophilized powder form, in 100mcg vials.
About Triptorelin: Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR; Ki = 0.3 nM in CHO cells expressing the human receptor).1 It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 μM, respectively).2 Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 μM, respectively).3 It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM.2 It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day.4 Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.
BUY Triptorelin GnRH Today from International Peptides!
We offer the highest grade and purity of triptorelin for sale at a competitive price in the USA. For best results buy triptorelin peptides of the highest quality from International Peptides.
For more information on Triptorelin peptide please visit Pubmed.
References & Product Citations
Product Description References
1. Characterization of 12 GnRH peptide agonists – a kinetic perspective. Br. J. Pharmacol. 173(1), 128-141 (2016).
2. Development of new gonadotropin-releasing hormone-modified dendrimer platforms with direct antiproliferative and gonadotropin releasing activity. J. Med. Chem. 60(20), 8309-8320 (2017).
3. Receptors for luteinizing hormone-releasing hormone (GnRH) as therapeutic targets in triple negative breast cancers (TNBC). Target Oncol. 10(3), 365-373 (2015).
4. Rapid suppression of plasma testosterone levels and tumor growth in the dunning rat model treated with degarelix, a new gonadotropin-releasing hormone antagonist. J. Pharmacol. Exp. Ther. 320(3), 1113-1118 (2007).
|Unit Size||100 mcg/vial|
|Unit Quantity||1 Vial|
|Solubility||>Soluble in water or 1% acetic acid|
|Storage||Lyophilized GnRH Triptorelin is stable at room temperature for 90 days, however it should be stored in a freezer below -8C for any extended period of time.|
|Safety Information||For Research Only. Not Intended for Diagnostic or Therapeutic Use.|